NOT KNOWN DETAILS ABOUT MAKATUSSIN SYROP

desvenlafaxine will improve the amount or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by approximately 50%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive days q